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SUMMARY:Roles of TCR signal strength and duration in driving T cell develo
 pment\, differentiation and function - Dr David Bending\; Institute of Imm
 unology and Immunotherapy\, College of Medical and Dental Sciences\, Unive
 rsity of Birmingham
DTSTART:20210310T150000Z
DTEND:20210310T160000Z
UID:TALK154453@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:David undertook his PhD studies in the laboratory of Prof. Ann
 e Cooke\, University of Cambridge\, where he was amongst the first to docu
 ment Th17 cell plasticity in autoimmune conditions. In 2011 he was awarded
  an Arthritis Research UK fellowship to explore the stability of regulator
 y T cells in juvenile arthritis under the mentorship of Prof Lucy Wedderbu
 rn at UCL. Following this he obtained a postdoc position in the lab of Dr.
  Masahiro Ono at Imperial College London\, where together they co-invented
  the Nr4a3-Timer of cell kinetics and activity (Tocky) tool\, which monito
 rs the temporal dynamics of distal TCR signalling. In 2018 he started his 
 own research group at the Institute of Immunology and Immunotherapy at the
  University of Birmingham\, and was awarded an MRC Career Development fell
 owship in 2020.  \n\nMajor research questions within the laboratory are: \
 n\n1) How does antigen modify distal T cell receptor signalling to dictate
  the nature of T cell immunity? \n\n2) How can we optimize the study of TC
 R signalling events in vivo during immune responses? \n\n3) How do T cell 
 targeting immunotherapies regulate the T cell response and can we use this
  to monitor responses to immune checkpoint blockade?\n\nJoin the webinar l
 ive using this link - https://zoom.us/j/97077462252
LOCATION:Online via zoom
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