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SUMMARY:Tooth Regeneration and Repair: Dentistry in the 21st century - Pro
 fessor Paul Sharpe\, King's College London\, Head of the Centre for Cranio
 facial &amp\; Regenerative Biology\, Dickinson Professor of Craniofacial B
 iology.
DTSTART:20201130T193000Z
DTEND:20201130T210000Z
UID:TALK154537@talks.cam.ac.uk
CONTACT:John Cook
DESCRIPTION:Stem cells can be identified in the stroma (connective tissue)
  of most tissues and organs. These cells provide a source of cells that be
 come activated upon tissue damage to generate differentiated cell types th
 at promote tissue repair. Specific targeting of these resident stem cells 
 has become a major goal for regenerative therapies.\n\nUsing the mammalian
  tooth as an easily accessible model organ\, we have developed a novel dru
 g treatment (ReDent) that activates resident stem cells in the tooth pulp 
 to differentiate into the specialised cell type (odontoblasts) that produc
 e reparative dentine. ReDent thus promotes self-repair of teeth following 
 caries removal. ReDent is anticipated to be in clinical trials in the next
  12 months. These same principles are also being applied to the developmen
 t of stem cell-based treatments for periodontal disease.\n\nTeeth are curr
 ently replaced using dental implants or prostheses (false teeth). The ulti
 mate goal of regenerative dentistry is to use bioengineering approaches to
  develop a method that allows a complete new functional tooth to grow in t
 he mouth. The basic proof-of-principle showing this is possible was establ
 ished several years ago. Our latest progress in this area will be presente
 d and the remaining obstacles discussed.
LOCATION:Location: Zoom. See CSAR emails for joining information.
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