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SUMMARY:First a war then a dance: How sensory organs take shape - Anna Erz
 berger (EMBL Heidelberg\, Germany)
DTSTART:20210118T143000Z
DTEND:20210118T160000Z
UID:TALK154711@talks.cam.ac.uk
CONTACT:98764
DESCRIPTION:Actively regulated symmetry breaking\, which is ubiquitous in 
 biological cells\, underlies phenomena such as directed cellular movement 
 and morphological polarization. Here\, we investigate how an organ-level p
 olarity pattern emerges through symmetry breaking at the cellular level du
 ring the formation of a mechanosensory organ. Combining theory\, genetic p
 erturbations and in vivo imaging\, we study the development and regenerati
 on of the fluid-motion sensors in the zebrafish’s lateral line. We find 
 that two interacting symmetry-breaking events—one mediated by biochemica
 l signalling and the other by cellular mechanics—give rise to precise ro
 tations of cell pairs\, which produce a mirror-symmetric polarity pattern 
 in the receptor organ. 
LOCATION:Online
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