BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:From cell dynamics to robust tissue folding - Magali Suzanne
DTSTART:20210201T143000Z
DTEND:20210201T153000Z
UID:TALK154717@talks.cam.ac.uk
CONTACT:98764
DESCRIPTION:Mechanical forces are critical regulators of cell shape change
 s and tissue remodelling during developmental morphogenetic processes. Rec
 ently\, we revealed that apoptotic cells\, far from being eliminated passi
 vely\, are generating apico-basal forces that constitute an important mech
 anical signal involved in epithelial folding in the developing leg of Dros
 ophila. Here\, I will present more recent works\, based on this initial di
 scovery regarding the cellular mechanism responsible for force generation 
 in apoptotic cells and the potential conservation of this mechanism in ver
 tebrate. I will further discuss the surprising similarities of the mechani
 cal impact of apoptotic cells to the one of ingressing cells undergoing EM
 T on tissue remodelling. Finally\, I will present data regarding the mecha
 nics of morphogenesis robustness involving Myosin II planar polarity and t
 he Arp2/3 complex. 
LOCATION:Online
END:VEVENT
END:VCALENDAR