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SUMMARY:Generating order out of (pseudo)chaos during vertebrate retinal la
 mination - Caren Norden
DTSTART:20210208T143000Z
DTEND:20210208T153000Z
UID:TALK154720@talks.cam.ac.uk
CONTACT:98764
DESCRIPTION:One important question in developmental neurobiology is how co
 llective cell behaviour ensures the reproducible formation of a healthy an
 d functional brain. We explore this question using the vertebrate retina a
 s a model tissue. The retina is the part of the central nervous system ded
 icated to transmit visual information from the environment to the brain. T
 he mature retina consists of five main types of neurons in defined laminae
  giving the whole organ a structured appearance. This neuronal lamination 
 pattern is strikingly conserved between vertebrates including humans. A re
 cent focus of our work is to understand how this laminated structure arise
 s reproducibly. In the retina\, in contrast to other parts of the brain\, 
 growth and neuronal lamination occur in parallel. This means that prolifer
 ation and neuronal migration need to be coordinated to ensure the continue
 d generation of progenitors while at the same time enable neuronal positio
 ning. Using long term imaging by light sheet microscopy in combination wit
 h quantitative image analysis we explore the interplay of these phenomena 
 for different neuronal cell types. Overall\, the understanding the positio
 ning of different neuronal cell types in the context of general tissue dev
 elopment will contribute to detangle the complex\, multi-scale event of re
 tinogenesis. This in turn will generate insights on the reproducible gener
 ation of complex including the intriguing brain.
LOCATION:Online
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