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SUMMARY:Cross-Kingdom RNAi and extracellular vesicle-mediated small RNA tr
 afficking between plants and fungal pathogens - Prof Hailing Jin\, UCR Riv
 erside
DTSTART:20210318T130000Z
DTEND:20210318T140000Z
UID:TALK154897@talks.cam.ac.uk
CONTACT:85030
DESCRIPTION:Communication between plants and interacting microorganisms re
 quires the secretion and uptake of molecules to and from the interacting o
 rganisms. We discovered that some small RNAs from eukaryotic pathogens\, s
 uch as Botrytis cinerea\, are delivered into plant cells and hijack host R
 NAi machinery to suppress host immunity genes (Weiberg et al.\, Science 20
 13). We further demonstrated that such cross-kingdom RNAi is bi-directiona
 l (Wang et al.\, Nature Plants 2016). Plants utilize extracellular vesicle
 s\, mainly exosomes\, to send sRNAs into fungal cells to silence virulence
 -related genes (Cai et al.\, Science 2018). Recently\, we identified a set
  of RNA-binding proteins that contribute to the selective loading and stab
 ilization of small RNAs in the extracellular vesicles (He et al.\, Nature 
 Plants\, 2021).\n\nFurthermore\, we found that many fungal pathogens can t
 ake up RNAs from the environment. Applying small RNAs or double-stranded R
 NAs that target fungal virulence-related genes on plants can inhibit funga
 l diseases (Wang et al\,\, Nature Plants\, 2016). Such pathogen gene-targe
 ting RNAs represent a new generation of fungicides that are durable and ec
 o-friendly.\n\nContact reception@plantsci.cam.ac.uk for a Zoom link prior 
 to a talk if you are not on our mailing list. Due to having to go onine\, 
 we are restricting the talks to University of Cambridge and alumni to keep
  them as informal as possible.
LOCATION:Online
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