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SUMMARY:Dynamics of human life-course antibody profile to influenza A(H3N2
 ) - Bingyi Yang\, University of Hong Kong
DTSTART:20210115T100000Z
DTEND:20210115T110000Z
UID:TALK154918@talks.cam.ac.uk
CONTACT:Theodora Anderson
DESCRIPTION:Pre-existing antibodies against antigenically variable pathoge
 ns that arise from multiple infections over a life time interfere with imm
 une responses to new exposures through both positive and negative feedback
 s. Such complex interaction – analogical to ecological systems - may exh
 ibit intrinsic temporal cycles but has not been investigated. This study r
 eported the existence of intrinsic cycles in human antibody profiles of in
 fluenza A(H3N2) at both individual- and population-level using antibody pr
 ofiles from a cohort in Guangzhou and found these cycles can be recovered 
 by models incorporating cross-reactions between strains and the herd prote
 ction could recover these two cycles.\n\nBio: I obtained my Ph.D. in infec
 tious disease epidemiology from The University of Hong Kong and postdoctor
 al training in University of Florida with Prof. Derek Cummings. My researc
 h interest is understanding the transmission dynamics of infectious diseas
 es with a focus on seroepidemiology.
LOCATION:Zoom
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