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SUMMARY:SARS-CoV-2 serosurveillance: local efforts and global consideratio
 ns - Saki Takahashi\, University of California\, San Francisco
DTSTART:20210319T150000Z
DTEND:20210319T160000Z
UID:TALK154945@talks.cam.ac.uk
CONTACT:Theodora Anderson
DESCRIPTION:Abstract: Serosurveys are a key resource for measuring the pro
 portion of the population that has been infected by SARS-CoV-2. However\, 
 reported assay performance characteristics are usually only applicable to 
 early convalescent samples from hospitalized patients with severe disease\
 , whereas accurate estimation of population seroprevalence relies on adequ
 ate characterization of assay sensitivity to detect prior infections in th
 e general population. In this talk\, I'll present our recent work on chara
 cterizing the heterogeneity in antibody responses between assays\, disease
  severity\, and over time among participants in a post-infection cohort\, 
 as well as on developing a framework to incorporate these heterogeneities 
 into more accurate seroprevalence estimation. I'll also discuss a platform
  that our group has piloted to test remnant samples from two hospital netw
 orks in San Francisco for SARS-CoV-2 antibodies\, which could be leveraged
  for broader application beyond this local context and for other pathogens
 .\nBio: I am a postdoctoral scholar and a Schmidt Science Fellow at the EP
 PIcenter at UCSF. I'm broadly interested in understanding the interactions
  between pathogens and the host immune response across scales. In my post-
 doc\, I've been combining high-throughput serological data with models to 
 study how individuals acquire clinical immunity to malaria\, and using ser
 osurveillance to understand the magnitude of the SARS-CoV-2 pandemic. I co
 mpleted my PhD in 2019 at Princeton University with Jessica Metcalf and Br
 yan Grenfell.
LOCATION:Venue to be confirmed
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