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SUMMARY:Probabilistic refinement of cellular pathway models. - Florian Mar
 kowetz\, Cancer Research UK Cambridge Research Institute
DTSTART:20090121T160000Z
DTEND:20090121T170000Z
UID:TALK15509@talks.cam.ac.uk
CONTACT:Neil Walton
DESCRIPTION:Building better models of cellular pathways is one of the majo
 r\nchallenges of systems biology and functional genomics. There is a\nneed
  for methods to build on established expert knowledge and\nreconcile it wi
 th results of high-throughput studies. Available data\nsources are very he
 terogeneous and need to be combined in a way\nspecific for the part of the
  pathway they are most informative for.\nAlso\, some data sources like pro
 tein domains or phosphorylation\nstates have so far been under-utilized fo
 r inferring pathway\nstructure. Here we present a compartment-specific str
 ategy to refine a given\npathway hypothesis from a compendium of heterogen
 eous data sources\,\nwhich includes novel methodology to integrate protein
  attributes. We\ndemonstrate the power of our approach in a case study in 
 S.\ncerevisiae and show that it can assist experimentalists in planning\nf
 uture studies  by proposing testable extensions and refinements of\na give
 n pathway hypotheses. 
LOCATION:MR15\, CMS\, Wilberforce Road\, Cambridge\, CB3 0WB
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