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SUMMARY:Trials and Tribulations of Centromeric Sequence Assembly - Speaker
  to be confirmed
DTSTART:20210113T130000Z
DTEND:20210113T140000Z
UID:TALK155257@talks.cam.ac.uk
CONTACT:Dr Qi Wang
DESCRIPTION:Every eukaryotic chromosome has a centromere\, a locus\nrespon
 sible for poleward movement at mitosis and meiosis. Despite the essential 
 function of centromere regions\, many key centromeric proteins and the und
 erlying DNA sequences are not conserved\, and have been reported to be abl
 e to evolve rapidly – which is referred to as the ‘centromere paradox
 ’. However\, a complete understanding of centromere function and evoluti
 on has been limited\, primarily due to these regions being highly repetiti
 ve and a lack of fully assembled centromeric sequences in many species. Re
 cent advances in long read DNA sequencing provide an opportunity to map an
 d understand the structure of\ncentromeres for the first time. This talk w
 ill present work from our ongoing project to utilise Nanopore sequencing t
 o map across the Arabidopsis thaliana centromeres\, to investigate the gen
 etic and epigenetic landscape of these regions.
LOCATION:You can sign up at  https://lists.cam.ac.uk/mailman/listinfo/plan
 tsci-bioinfo . Zoom link will be sent to this list on the day of the meeti
 ng.
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