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SUMMARY:Targeting protein aggregate clearance pathways to slow neurodegene
 ration in prion disorders - Dr Christina J. Sigurdson\, Center for Veterin
 ary Sciences and Comparative Medicine\, UC San Diego
DTSTART:20210428T150000Z
DTEND:20210428T160000Z
UID:TALK155272@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Experimental studies indicate prion aggregates rapidly transit
  throughout the central nervous system\, yet the relationship between the 
 prion structure and genetic modifiers that impact aggregate spread are poo
 rly understood. We and others previously showed profound differences in th
 e neuroinvasion of prions\, depending on the strain. Using a series of est
 ablished and new mouse models to alter the extracellular matrix or the pri
 on protein\, we investigated the determinants of prion propagation through
  the neuron and through the CNS. \n\nChaired by Dr Raymond Bujdoso\n
LOCATION:Venue to be confirmed
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