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SUMMARY:Models of neurological disease  - Prof. Roger D Kamm
DTSTART:20210203T160000Z
DTEND:20210203T170000Z
UID:TALK155788@talks.cam.ac.uk
CONTACT:Anne Jacobs
DESCRIPTION:Many of the most debilitating and life-threatening diseases ar
 e associated with the central nervous system. Some\, such as neurodegenera
 tive diseases\, predominately afflict our aging population. Yet others suc
 h as brain cancers and ALS are prevalent at all ages. In this presentation
 \, models will be presented that attempt to recapitulate key aspects of th
 e central or peripheral nervous system\, both to probe the disease process
 \, and as platforms to screen for new therapeutics. Four examples will be 
 presented. First\, a model for the healthy blood-brain barrier and neurova
 scular unit have been developed in order to capture the essential aspects 
 associated with these diseases. Second\, the blood-brain barrier model is 
 used to study metastasis of cancers to the brain\, as well as primary glio
 blastoma. In the third part of the talk\, a model for the healthy and dise
 ased neuromuscular junction will be presented as a step toward developing 
 therapeutic strategies for treating ALS.  Finally\, a model for cerebral a
 myloid angiopathy\, often associated with Alzheimer’s disease\, will be 
 discussed as a disease model and for its drug screening potential.
LOCATION:https://zoom.us/j/92316143946?pwd=RmFpcnlrNWkrUldWbzZRazhxRjM2QT0
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