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SUMMARY:Microglia shape neuro-vascular responses via compartment-specific 
 mechanisms - Adam Denes\, Institute of Experimental Medicine\, Budapest
DTSTART:20210201T160000Z
DTEND:20210201T170000Z
UID:TALK155905@talks.cam.ac.uk
CONTACT:75382
DESCRIPTION:Microglia are key regulators of inflammatory processes in the 
 CNS. Microglial activity is altered in common brain diseases and changes i
 n microglial function have major impact on outcome in experimental models 
 of neurological disorders. However\, the mechanisms through which microgli
 a contribute to the maintenance of normal brain function and impact on com
 mon CNS disorders are not well understood. We have recently identified a n
 ovel form of microglia-neuron interaction\, which is present in the majori
 ty of neurons in mouse and human brain. Somatic microglia-neuron junctions
  possess specialized nanoarchitecture optimized for purinergic signaling. 
 We show that activity of neuronal mitochondria is linked with microglial j
 unction formation\, which is induced rapidly in response to neuronal activ
 ation and blocked by inhibition of P2Y12 receptors. Brain injury-induced c
 hanges at somatic junctions trigger P2Y12-dependent microglial neuroprotec
 tion\, regulating neuronal calcium load and functional connectivity. Micro
 glia also shape cerebrovascular responses via compartment-specific actions
  in the neurovascular unit. Our results suggest that motile microglial pro
 cesses exert fine-tuned actions to influence the functioning of neurons an
 d the vasculature in the healthy and the injured brain. Understanding the 
 mechanisms of microglia-neuron-vascular interactions is likely to help the
  identification of novel therapeutic targets in common neurological disord
 ers.
LOCATION:https://zoom.us/j/94352010365?pwd=QmxKL3FwKytYZDA4S2JFYTN0YkpwZz0
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