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SUMMARY:Symmetry breaking and self-organization in intestinal organoids - 
 Prof. Prisca Liberali\; SNSF Professor and Research Group Leader\, Friedri
 ch Miescher Institute for Biomedical Research (FMI)
DTSTART:20210602T113000Z
DTEND:20210602T123000Z
UID:TALK155941@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Multicellular organisms are composed of cells and tissues with
  identical genomes but different properties and functions. They all develo
 p from one cell to form multicellular structures of astounding complexity.
  During development\, in a series of spatio-temporal coordinated steps\, c
 ells differentiate into different cell types and establish tissue-scale ar
 chitectures and functions. Throughout life\, continuous tissue renewal and
  regeneration is required for tissue homeostasis\, which also requires fin
 e-tuned spatio-temporal coordination of cells. I will discuss how cellular
  interactions generate the specific contexts and spatio-temporal coordinat
 ion underlying development and regeneration and how we specifically develo
 p new technologies to investigate what are the molecular and physical mech
 anisms that allow a cell\, in a tissue\, to sense its complex environment\
 , to take individual coordinated decisions. Moreover\, I will discuss the 
 molecular mechanisms of intestinal organoid self-organization and the role
  of cell-to-cell variability in populations of differentiating cells durin
 g symmetry breaking.\n\n\nPrisca Liberali has been trained as a physical o
 rganic chemist\, and during her postdoc she has developed new single-cell 
 methods and statistical approaches to model complex patterns of cell-to-ce
 ll variability. Since 2015\, Prisca runs her research group at the FMI\, i
 n which she continues to innovate on image-based single-cell approaches. S
 he has set up novel light-sheet and high-throughput imaging approaches to 
 quantify organoids. This has recently led to a seminal paper by her group 
 showing that initial symmetry breaking in intestinal organoids is determin
 ed by variation in mechano-sensing in individual cells. In addition\, she 
 has successfully applied this platform to achieve the first high-content s
 creen of compounds that interfere with intestinal regeneration and identif
 ied novel compounds that improve intestinal regeneration in vivo.\n\n\n\nJ
 oin the webinar live using this link:\nhttps://zoom.us/j/95028129214
LOCATION:Zoom webinar
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