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SUMMARY:Inhomogeneous exclusion processes and the efficiency of mRNA trans
 lation - Joachim Krug\, University of Cologne
DTSTART:20210216T130000Z
DTEND:20210216T140000Z
UID:TALK156061@talks.cam.ac.uk
CONTACT:Patrick Pietzonka
DESCRIPTION:Zoom link: https://maths-cam-ac-uk.zoom.us/j/94018037756\n\nAl
 l living cells synthesize proteins by transcribing the hereditary informat
 ion in their DNA into strands of messenger RNA which are \nsubsequently tr
 anslated into amino acid sequences. The genetic code that assigns triplets
  of nucleotides (codons) to their \ncorresponding amino acids is redundant
 \, since most amino acids are encoded by several codons. Mutations that ch
 ange the DNA \nsequence but leave the amino acid sequence unchanged are ca
 lled synonymous. Motivated by recent experiments on an antibiotic \nresist
 ance gene\, in this work we investigate genetic interactions between synon
 ymous mutations in the \nframework of exclusion models of translation. We 
 show that the range of possible interactions is markedly different dependi
 ng on \nwhether translation efficiency is assumed to be proportional to ri
 bosome current or ribosome speed. Based on a rigorous proof\nof a monotoni
 city property of the particle current in the inhomogeneous totally asymmet
 ric simple exclusion process\, we argue \nthat mutational effects on the r
 ibosome current have a definite sign that is independent of genetic backgr
 ound. In contrast\,\nthe effect-sign on ribosome speed can vary depending 
 on the presence of other mutations\, a result that is demonstrated using \
 nconfigurations of multiple translational bottlenecks induced by slow codo
 ns.
LOCATION:via zoom\, meeting ID 940-1803-7756
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