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SUMMARY:Challenges and Opportunities in Exploiting Reconsolidation to Trea
 t Mental Health Disorders - Dr Amy Milton\, University of Cambridge
DTSTART:20210506T113000Z
DTEND:20210506T123000Z
UID:TALK156268@talks.cam.ac.uk
CONTACT:87079
DESCRIPTION:*Abstract:*Despite advances in pharmacological and psychologic
 al therapies over the past decades\, there is still an unmet need for new 
 treatment development for mental health disorders. One such potential trea
 tment is targeting the reconsolidation of maladaptive memories that suppor
 t mental health disorders such as post-traumatic stress disorder (PTSD) an
 d drug addiction. Over the past 15 years\, we have aimed to exploit the me
 mory reconsolidation process to disrupt both pavlovian and instrumental me
 mories supporting maladaptive behaviours. Using pharmacological and non-ph
 armacological approaches\, we have found that reconsolidation-based interv
 entions can persistently reduce maladaptive behaviour in rodent models wit
 h relevance to mental health disorders. While challenges remain for the de
 velopment of reconsolidation-based interventions to treat mental health di
 sorders\, we conclude that this approach ultimately holds promise for tran
 slation to the clinical situation. \n\n\n\n*Biography:* Dr Amy L Milton is
  a University Senior Lecturer at the Department of Psychology\, University
  of Cambridge\, and the Ferreras-Willetts Fellow in Neuroscience at Downin
 g College\, Cambridge. Her research focuses on memory reconsolidation from
  a basic science perspective and in terms of its potential translation int
 o a novel form of treatment for mental health disorders. She received her 
 MA after specialising in Natural Sciences (Neuroscience) at Newnham Colleg
 e\, University of Cambridge\, and studied for her PhD in Behavioural Neuro
 science with Professor Barry Everitt at the Department of Experimental Psy
 chology\, University of Cambridge. She is the Principal Investigator of th
 e Memories in Neuropsychiatric Disorders (MiND) lab\, where her group are 
 using a combination of behavioural and molecular neurobiological approache
 s in rodents to understand how maladaptive emotional memories become modif
 iable\, and how they persist in the brain.
LOCATION: Webinar  (via Zoom online)
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