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SUMMARY: Fragments of stories: biophysics\, chemical biology and drug disc
 overy - Rod Hubbard\, University of York and Vernalis
DTSTART:20210128T103000Z
DTEND:20210128T113000Z
UID:TALK156400@talks.cam.ac.uk
CONTACT:Anne Jacobs
DESCRIPTION:The idea of screening a library of small compounds or fragment
 s to find starting points for drug discovery was established more than 20 
 years ago. Many fragment-derived compounds are now in clinical trials\, wi
 th a few now treating patients. The methods have recently been extended to
  chemical biology – using fragments as chemical tools to ask questions a
 bout a biological system.  \n \nIn this seminar\, I will briefly introduce
  the approach\, but the main focus will be on selected stories on using fr
 agments from work at Vernalis and York.  As well as drug discovery\, these
  include probing protein surfaces\, identifying potential mechanisms for d
 isrupting a molecular machine and improving the activity of industrial enz
 ymes.  Within these stories are useful lessons about the development and u
 se of biophysical methods for detecting and characterizing the interaction
  of small molecules with proteins.\n
LOCATION:https://zoom.us/j/98208866632?pwd=RW1QeWtUNzViZTRiVlBGU2d0b1Evdz0
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