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SUMMARY:Molecular Biology of Prion Infections - Prof. Adriano Aguzzi\, Uni
 versity hospital of Zurich
DTSTART:20210210T103000Z
DTEND:20210210T113000Z
UID:TALK156508@talks.cam.ac.uk
CONTACT:Anne Jacobs
DESCRIPTION:Transmissible spongiform encephalopathies (TSEs) are neurodege
 nerative diseases of humans and many animal species caused by prions. The 
 main constituent of prions is PrPSc\, an aggregated moiety of the host-der
 ived membrane glycolipoprotein PrPC. Prions were found to encipher many ph
 enotypic\, genetically stable TSE variants. The latter is very surprising\
 , since PrPC is encoded by the host genome and all prion strains share the
  same amino acid sequence. Here I will review what is known about the infe
 ctivity\, the neurotoxicity\, and the neuroinvasiveness of prions. Also\, 
 I will explain why I regard the prion strain question as a fascinating cha
 llenge – with implications that go well beyond prion science. Finally\, 
 I will report some recent results obtained in my laboratory\, which is att
 empting to address the strain question and some other basic issues of prio
 n biology with a “systems” approach that utilizes organic chemistry\, 
 photophysics\, proteomics\, and mouse transgenesis.
LOCATION:https://zoom.us/j/99760374933?pwd=cXlRUVBabWpCUWZ4NHRGWnRmLzV3dz0
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