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SUMMARY:Glutamate receptors: from single molecules to physiology - Prof. V
 asanthi Jayaraman\, University of Texas Health Science Center
DTSTART:20210317T160000Z
DTEND:20210317T170000Z
UID:TALK156514@talks.cam.ac.uk
CONTACT:Akhila Kadgathur Jayaram
DESCRIPTION:Glutamate receptors mediate excitatory responses in the mammal
 ian central nervous system\, and ultimately control motor and cognitive fu
 nctions. AMPA mediate fast synaptic transmission by opening cation ion per
 meable channels upon binding glutamate. We use a combination of mutagenesi
 s\, single molecule FRET and luminescence resonance energy transfer method
 s\, along with electrophysiological measurements to map the conformational
  landscape that the underlies this gating process of channel opening and d
 esensitization in this protein.  We also investigate how the gating proper
 ties are modulated by the presence auxiliary subunits such as gamma2 and g
 amma 8\, as well as small molecule inhibitors\, and determine the changes 
 in the conformational landscape that underlie these modulatory functional 
 changes.
LOCATION:https://zoom.us/j/99203574537
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