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SUMMARY:Translational medicine in Alzheimer’s disease – taking the unf
 olded protein response as a therapeutic target in to clinical trials. - Dr
  Ben Underwood\, Deputy Medical Director CPFT
DTSTART:20210527T113000Z
DTEND:20210527T123000Z
UID:TALK156757@talks.cam.ac.uk
CONTACT:87079
DESCRIPTION:*Abstract*: Pioneering work by Professor Giovanna Mallucci her
 e in Cambridge has identified decreased protein synthesis arising from chr
 onic over-activation of the unfolded protein response as a key pathologica
 l event in dementia.  Furthermore\, work in her lab has identified a numbe
 r of licensed drugs as potentially reversing this and rescuing disease phe
 notypes.  In this talk I will recap some of this laboratory work before fo
 cussing on how we are translating this work in terms of experimental medic
 ine and clinical trials.\n\n*Biography:* Ben Underwood studied natural sci
 ence at Oxford University and medicine in London.  He then worked in neuro
 logy and Accident and Emergency before coming to Cambridge in 2002.  Here 
 he completed his psychiatric training and a PhD with Professor David Rubin
 sztein looking at the application of autophagy up-regulating drugs as poss
 ible disease modifying agents in dementia.  He carried out the first trial
  of one of these drugs\, rilmenidine\, in Huntington’s disease patients.
   He has been a consultant old age psychiatrist for ten years but has main
 tained an interest in clinical trials in dementia.  He is currently the cl
 inical lead for dementia in the East of England for the Clinical Research 
 Network (CRN) and national lead for stratified medicine in dementia and co
 -organises the University MPhil in translational medicine.  \n\nBen is the
  deputy medical director at CPFT and clinical director of the older people
  and adult community directorate and the Windsor Unit\, which was a key co
 ntributor to the successful trial of the Oxford coronavirus vaccine.  Enco
 uraged by this success he will become a lecturer in older people’s healt
 h at the University of Cambridge from April 2021 and clinical director of 
 the Gnodde Goldman Sachs translational neuroscience unit\, which seeks to 
 be a vehicle connecting patients with dementia to the latest research thro
 ugh experimental medicine and clinical trials with a focus on translating 
 the basic science discoveries from Professor Giovanna Mallucci. 
LOCATION: Webinar  (via Zoom online)
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