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SUMMARY:LMB Seminar: Functions of Ribosome-Associated Chaperones in Health
  and Disease   - Prof. Dr. Elke Deuerling\, Chair of Molecular Microbiolog
 y\, University of Konstanz\, Germany
DTSTART:20210316T110000Z
DTEND:20210316T120000Z
UID:TALK156868@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:The continuous refreshment of the proteome is critical to main
 tain protein homeostasis and to adapt cells to changing conditions. Thus\,
  de novo protein biogenesis by ribosomes is vitally important to every cel
 lular system. This process is delicate and error-prone and requires\, besi
 des cytosolic chaperones\, the guidance by a specialized set of molecular 
 chaperones including the bacterial trigger factor (TF)\, the archaeal and 
 eukaryotic nascent polypeptide-associated complex (NAC)\, and the eukaryot
 ic ribosome-associated complex (RAC).\nThese chaperones  bind transiently 
 to the translation machinery and the nascent protein to support early fold
 ing events and to regulate cotranslational protein transport. Moreover\, r
 ecent findings indicate that NAC is also a very potent suppressor of aggre
 gation and proteotoxicity in vivo and in vitro of mutant PolyQ-expanded pr
 oteins associated with human diseases like Huntington’s disease and spin
 ocerebellar ataxias. In my talk I will focus on the most recent findings a
 bout NAC and its potential mechanisms of action in health and disease.
LOCATION:Webinar - https://zoom.us/j/97041423092?pwd=dDFuelNtb0o2cTdWL1Bab
 FBhbldFQT09 
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