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SUMMARY:Organization of Midbrain Serotonin System - Dr Jing Ren\, MRC Labo
 ratory of Molecular Biology
DTSTART:20210309T160000Z
DTEND:20210309T170000Z
UID:TALK156943@talks.cam.ac.uk
CONTACT:Dr Dervila Glynn
DESCRIPTION:Theme: *Neurons\, Circuits & Networks*\n\nThe serotonin system
  is the most frequently targeted neural system pharmacologically for treat
 ing psychiatric disorders\, including depression and anxiety. Serotonin ne
 urons of the dorsal and median raphe nuclei (DR\, MR) collectively innerva
 te the entire forebrain and midbrain\, modulating diverse physiology and b
 ehaviour. By using viral-genetic methods\, we found that DR serotonin syst
 em contains parallel sub-systems that differ in input and output connectiv
 ity\, physiological response properties\, and behavioural functions. To ga
 in a fundamental understanding of the molecular heterogeneity of DR and MR
 \, we used single-cell RNA- sequencing (scRNA-seq) to generate a comprehen
 sive dataset comprising eleven transcriptomically distinct serotonin neuro
 n clusters. We generated novel intersectional viral-genetic tools to acces
 s specific subpopulations. Whole-brain axonal projection mapping revealed 
 that the molecular features of these distinct serotonin groups reflect the
 ir anatomical organization and provide tools for future exploration of the
  full projection map of molecularly defined serotonin groups. The molecula
 r architecture of serotonin system lays the foundation for integrating ana
 tomical\, neurochemical\, physiological\, and behavioural functions.\n\nBi
 ography\nJing pursued her Ph.D under the supervision of Dr. Minmin Luo\, a
 t the National Institute of Biological Sciences\, Beijing (NIBS). After th
 at\, she did postdoctoral research in Dr. Liqun Luo’s lab at Stanford Un
 iversity and started the journey of investigating the serotonin system. Ji
 ng became a junior group leader at the MRC Laboratory of Molecular Biology
  in January 2020. Currently her team is working on revealing the developme
 ntal assembly of the serotonin system. \n\nRegister in advance for this me
 eting:\nhttps://us02web.zoom.us/meeting/register/tZMrdeigpz4oHtHLvS6q4SklW
 CwUNsWcQ82U \n\nAfter registering\, you will receive a confirmation email 
 containing information about joining the meeting.
LOCATION:Register on Zoom - link in abstract
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