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SUMMARY:Regenerative Neuroimmunology - a stem cell perspective - Professor
  Stefano Pluchino\, Clinical Neurosciences
DTSTART:20210601T150000Z
DTEND:20210601T160000Z
UID:TALK156982@talks.cam.ac.uk
CONTACT:Dr Dervila Glynn
DESCRIPTION:Theme: *Beyond the Neuron: glia\, vascular and immune cells*\n
 \nThere are currently no approved therapies to slow down the accumulation 
 of neurological disability that occurs independently of relapses in multip
 le sclerosis (MS). International agencies are engaging to expedite the dev
 elopment of novel strategies capable of modifying disease progression\, ab
 rogating persistent CNS inflammation\, and support degenerating axons in p
 eople with progressive MS. \nUnderstanding why regeneration fails in the p
 rogressive MS brain and developing new regenerative approaches is a key pr
 iority for the Pluchino Lab.\nIn particular\, we aim to elucidate how the 
 immune system\, in particular its cells called myeloid cells\, affects bra
 in structure and function under normal healthy conditions and in disease.\
 nOur objective is to find how myeloid cells communicate with the central n
 ervous system and affect tissue healing and functional recovery by stimula
 ting mechanisms of brain plasticity mechanisms such as the generation of n
 ew nerve cells and the reduction of scar formation. \nApplying combination
  of state-of-the-art omic technologies\, and molecular approaches to study
  murine and human disease models of inflammation and neurodegeneration\, w
 e aim to develop experimental molecular medicines\, including those with s
 tem cells and gene therapy vectors\, which slow down the accumulation of i
 rreversible disabilities and improve functional recovery after progressive
  multiple sclerosis\, stroke and traumatic injuries.\nBy understanding the
  mechanisms of intercellular (neuro-immune) signalling\, diseases of the b
 rain and spinal cord may be treated more effectively\, and significant neu
 roprotection may be achieved with new tailored molecular therapeutics.\n\n
 Stefano received his MD and PhD degrees at the University of Siena\, Italy
 \, with additional training at Cambridge University\, UK. He is currently 
 University Reader in Regenerative Neuroimmunology (2016) and Honorary Cons
 ultant in Neurology\, within the Department of Clinical Neurosciences at C
 ambridge University.\nHe has a strong interest in Regenerative Neuroimmuno
 logy\, and his research over the last 20 years has recalibrated the classi
 cal view that cellular grafts only function through structural cell replac
 ement and opened up a new therapeutic avenue by which to use exogenously d
 elivered stem cells\, or even stem cell-derived acellular therapies that i
 nclude extracellular vesicles and exosomes. \nThe Pluchino team studies wh
 ether the accumulation of neurological disability observed in patients wit
 h chronic inflammatory neurological conditions can be slowed down using ne
 xt generation molecular therapies. The overarching aim is to understand th
 e basic mechanisms that allow exogenously delivered stem cells\, gene ther
 apy vectors and/or exosomes to create an environment that preserves damage
 d axons or prevents neurons from dying. Such mechanisms may be harnessed a
 nd used to modulate disease states in an effort to repair and/or regenerat
 e critical components of the nervous system. \nHe is the recipient of nume
 rous national and international awards\, among which the Italian Multiple 
 Sclerosis Foundation (FISM) Rita Levi-Montalcini prize for outstanding res
 earch in MS (2007)\, the 2009 Italian Ministry of Health Young Investigato
 r Award and the 2010 European Research Council (ERC) Starting Independent 
 Award. His laboratory research on Regenerative Neuroimmunology is document
 ed in >220 publications and have received >12.500 citations (ISI-WOK)\, wi
 th a Hirsch Factor of 50.\n\nRegister in advance for this meeting:\nhttps:
 //us02web.zoom.us/meeting/register/tZYkde2vpzkqHd3781cn6IVUGzMQA106vt4U \n
 \nAfter registering\, you will receive a confirmation email containing inf
 ormation about joining the meeting.
LOCATION:Register on Zoom - link in abstract
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