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SUMMARY:Reprogramming and plasticity of epigenetic regulation - Prof Petra
  Hajkova\; MRC London Institute of Medical Sciences (LMS)\, London
DTSTART:20210324T150000Z
DTEND:20210324T160000Z
UID:TALK157033@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Stability of the epigenetic landscape underpins maintenance of
  the cell type specific transcriptional profile. DNA methylation as one of
  the main repressive epigenetic systems has been shown to be important for
  long term gene silencing\; its loss leading to ectopic and aberrant trans
 cription in differentiated cells and cancer. Interestingly\, the developin
 g germ line endures global changes in DNA methylation in the absence of wi
 despread transcriptional activation. \n\nI will discuss our efforts to dis
 sect the mechanisms of the germline global loss of DNA methylation and our
  recent results uncovering the plasticity and cross-talk between the epige
 netic silencing systems that assure the transcriptional stability in the h
 ypomethylated mouse germ line.  \n\n\nJoin the webinar live using this lin
 k – https://zoom.us/j/91092617293 
LOCATION:Online via zoom
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