BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:GABA relates to functional connectivity changes and retention in v
 isuomotor adaptation - Caroline Nettekoven\, Brain Mapping Unit\, Universi
 ty of Cambridge
DTSTART:20210203T160000Z
DTEND:20210203T170000Z
UID:TALK157117@talks.cam.ac.uk
CONTACT:Katharina Zuhlsdorff
DESCRIPTION:Interacting with our ever-changing physical environment requir
 es continual recalibration of the motor system. One mechanism by which thi
 s occurs is motor adaptation. Understanding how motor adaptation is implem
 ented by the human brain\, how different regions work in concert to retain
  adaptive movement accuracy\, and how this function is linked to metabolic
  use of neurochemicals poses an important challenge in neuroscience. In hu
 mans\, motor sequence learning is related to concentration of γ-aminobuty
 ric acid (GABA) in the primary motor cortex (M1). However\, the role of M1
  GABA in adaptation – where behaviour is acquired outside M1 but retaine
 d within M1 – is unclear. Here\, we used an ultra-high field MR multimod
 al acquisition to address the hypothesis that M1 GABA and M1-Cerebellar fu
 nctional connectivity would relate to retention of adaptation\, but not ac
 quisition of adaptation. As such\, we demonstrate higher baseline M1 [GABA
 ] relates to greater retention but does not relate to adaptation-acquisiti
 on. This relationship is mediated by change in M1-Cerebellar functional co
 nnectivity: higher M1 [GABA] relates to a decreased M1-Cerebellar connecti
 vity\, resulting in greater retention. These findings showed anatomical\, 
 neurochemical and behavioural specificity: As expected\, no relationship w
 as found between retention and a control metabolite\, M1 [Glutamate]\, as 
 well as retention and connectivity change between control regions and no r
 elationship was found between M1 [GABA] and behaviour in a control conditi
 on. The implication of a mechanistic link from neurochemistry to retention
  significantly advances our understanding of population variability in ret
 ention behaviour and provides a crucial step towards developing therapeuti
 c interventions to restore motor abilities.
LOCATION:Zoom
END:VEVENT
END:VCALENDAR