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SUMMARY:Rules of engagement: molecular arms races between host and viral g
 enomes - Dr. Harmit Singh Malik\, Professor\, Division of Basic Sciences &
 amp\; HHMI Investigator\, Fred Hutchinson Cancer Research Center
DTSTART:20210302T160000Z
DTEND:20210302T170000Z
UID:TALK157351@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:\nThe Malik lab studies the causes and consequences of genetic
  conflicts that take place between different genomes (e.g.\, host-virus in
 teractions) or between components of the same genome (e.g.\, chromosomal c
 ompetition at centromeric regions). We are interested in understanding the
 se Red Queen interactions\, or "molecular arms races" and how they drive r
 ecurrent genetic innovation\, from the perspective of both evolutionary bi
 ology and human disease. Antagonistic interactions drive host-virus evolut
 ionary arms-races\, which often manifest as recurrent amino acid changes (
 i.e.\, positive selection) at their protein-protein interaction interfaces
 . We investigated whether combinatorial or single-residue mutagenesis of p
 ositions under positive selection in host antiviral protein could alter or
  even enhance its restrictive properties. Using such studies\, we hope to 
 identify the rules and constraints shaping the evolutionary landscape and 
 potential of antiviral proteins. 
LOCATION:Webinar -  https://zoom.us/j/92208122335?pwd=UGJIN3k3TnJYNWloNFBh
 VDlOaldZUT09
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