BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Cavitation Enhanced Drug Delivery - Prof Eleanor Stride\, Institut
 e of Biomedical Engineering\, University of Oxford\, Old Road Campus\, Oxf
 ord OX3 7DQ\, UK
DTSTART:20210310T130000Z
DTEND:20210310T140000Z
UID:TALK157405@talks.cam.ac.uk
CONTACT:Alice Handy
DESCRIPTION:The hydrodynamic and mechanical effects produced by cavitation
  have been widely studied\, with applications ranging from turbomachinery 
 to tree growth. In the context of drug delivery these effects can be explo
 ited to dramatically improve the degree to which treatment can be targeted
  to specific sites within the body. This talk will describe the ways in wh
 ich specially designed cavitation nuclei in the form of solid\, liquid or 
 gas particles can be utilised to promote the controlled release and distri
 bution of drug molecules for localized delivery in the treatment of diseas
 es such as cancer and stroke. First\, the particles provide a means of enc
 apsulating drugs to avoid interaction with healthy tissue and/or deactivat
 ion before reaching the target site. Second\, the particles can be functio
 nalized to enable them to be targeted to a specific tissue volume in order
  to maximize the concentration of the drug. Third\, the release of the dru
 g can be controlled temporally and spatially by using focused ultrasound t
 o initiate cavitation only within the tumour. Fourth\, the fluid motion in
 duced by the cavitation activity significantly enhances transport of the d
 rug throughout the tissue volume compared to passive diffusion\; and final
 ly\, the acoustic emissions from the cavitation bubbles can be used to mon
 itor the treatment from outside the body.  The talk will conclude with dis
 cussion of a specific example of how cavitation mediated delivery is being
  utilized in the treatment of pancreatic cancer.
LOCATION:https://us02web.zoom.us/j/86850511398?pwd=RDJuZlg2d1RpVDFPZmQzNzF
 zQWZDdz09
END:VEVENT
END:VCALENDAR