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SUMMARY:Models for tetrapod joint patterning: why does a finger have three
  knuckles? - Dr. Tom Hiscock (University of Aberdeen) 
DTSTART:20210317T170000Z
DTEND:20210317T180000Z
UID:TALK157435@talks.cam.ac.uk
CONTACT:Dr. Adrien Hallou
DESCRIPTION:Repeated joints are a hallmark feature of the tetrapod limb\, 
 and their patterning is a key step during limb development. Whilst the mol
 ecular regulation of joint formation is well-studied\, we have an incomple
 te understanding of what controls the location\, number and orientation (i
 .e. the pattern) of joints within each digit. Here\, inspired by published
  gene expression profiles\, we propose a dot-stripe mechanism for joint pa
 tterning\, which comprises two coupled Turing systems. Our mathematical mo
 del can explain normal joint morphology in wildtype limbs\, hyperphalangy 
 in cetacean flippers\, mutant phenotypes with misoriented joints and sugge
 sts a reinterpretation of polydactylous Ichthyosaur fins as a polygonal jo
 int lattice. We extend our model to suggest that the insights from Turing-
 like dot-stripe models apply regardless of the biological specifics of the
  underlying mechanism\, thus providing a unifying framework to understand 
 autopodial joint patterning across the tetrapod lineage.
LOCATION:Webinar
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