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SUMMARY:Microglia at the interface of chronic neurodegeneration and system
 ic inflammation - Colm Cunningham\, Institute of Neuroscience\, Trinity Co
 llege Dublin.
DTSTART:20210301T160000Z
DTEND:20210301T170000Z
UID:TALK157474@talks.cam.ac.uk
CONTACT:47293
DESCRIPTION:It is now clear that neuroinflammation is an important feature
  of chronic neurodegenerative disease. However it has also emerged that in
 flammation arising outside the brain exacerbates neuroninflammation and ca
 n contribute to cognitive and functional decline. In this talk I will disc
 uss some recent work on the role of the pattern recognition receptor STING
  and type I interferons in the progression of neurodegeneration. I will al
 so present new data on the role of the neurotransmitter acetylcholine in t
 he maintenance and restoration of the microglial homeostatic state. This l
 oss of acetylcholinergic tone\, just like evolving amyloidosis or progress
 ive synaptic loss in models of prion disease and Alzheimer's disease\, res
 ults in the development of a 'primed' state of microglial activation. This
  leaves these cells vulnerable to secondary systemic inflammatory stimuli\
 , which can trigger amplified IL-1beta and contribute to new neuronal dysf
 unction and injury. 
LOCATION:https://zoom.us/j/92332561649?pwd=cW83TGNIWVJ6OHk5T1puM0t4R2FrQT0
 9
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