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SUMMARY:3D genome folding\, unfolding\, and refolding in the mammalian bra
 in - Dr Jennifer E. Phillips-Cremins\; University of Pennsylvania\, Philad
 elphia USA
DTSTART:20210922T140000Z
DTEND:20210922T150000Z
UID:TALK157516@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:The Cremins Lab focuses on higher-order genome folding and how
  classic epigenetic modifications work through long-range\, spatial mechan
 isms to govern synaptic plasticity in healthy and diseased neural circuits
 . Much is already known regarding how transcription factors work in the co
 ntext of the linear genome to regulate brain development. Yet\, severe lim
 itations exist in our ability to engineer chromatin in neural circuits to 
 correct synaptic defects in vivo. At the lab’s inception\, it remained u
 nclear whether and how genome folding could functionally influence cell ty
 pe-specific gene expression. We have developed and applied new molecular a
 nd computational technologies to discover that nested subTADs and long-ran
 ge loops undergo marked reconfiguration during neural lineage commitment\,
  somatic cell reprogramming\, neuronal activity stimulation\, and in repea
 t expansion disorders. We demonstrated that loops induced by neural circui
 t activation\, engineered through synthetic architectural proteins\, and m
 iswired in fragile X syndrome were tightly connected to transcription\, th
 us providing early insight into the genome’s structure-function relation
 ship. We are currently focused on understanding how\, when\, and why 3D ge
 nome folding patterns contribute to synaptic plasticity and dysfunction in
  neural circuits. Addressing this knowledge gap will provide an essential 
 foundation for our long-term goal to engineer the 3D genome to reverse pat
 hologic synaptic defects in debilitating neurological diseases.\n\nJoin th
 e webinar live using this link – https://zoom.us/j/97304071166
LOCATION:Zoom webinar
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