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SUMMARY:A detailed look at tail-anchored membrane protein targeting - from
  metazoans to plants to protists - Prof. William Clemons\, Caltech
DTSTART:20210310T160000Z
DTEND:20210310T170000Z
UID:TALK157618@talks.cam.ac.uk
CONTACT:Anne Jacobs
DESCRIPTION:Membrane embedded proteins are central to life bridging across
  bilayers from the earliest development of biological membranes. Targeting
  and insertion of these protein to their respective membranes is a complic
 ated and essential process. Tail-anchor (TA) membrane proteins\, found in 
 nearly all biological membranes\, are an important and diverse class that 
 are unable to be targeted co-translationally. For eukaryotes\, the GET pat
 hway is responsible for delivering the most hydrophobic TA-clients to the 
 endoplasmic reticulum. Our lab has focused on structural and mechanistic s
 tudies of proteins in this pathway. The pathway begins when cytoplasmic ch
 aperones deliver the TA-client to Sgt2\, which then routes the proteins to
  the Get3 chaperone via a Get4/Get5 hetero-tetramer. Get3 forms a stable c
 omplex with the TA-client and delivers the proteins to the ER membrane. We
  have characterized these complexes using structural biology and biochemis
 try. I will discuss an overview of the pathway from our structural perspec
 tive focused on our yeast and mammalian pathways and including our recent 
 insights into the pathway differences in protists. From there\, I will sho
 w how Get3 homologs occurred early in evolution in both archaea and bacter
 ia. For the latter\, I will provide new evidence that a cyanobacterial hom
 olog has been conserved across evolution to occur in the chloroplasts of h
 igher plants.
LOCATION:https://zoom.us/j/98085179345
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