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SUMMARY:Microimplants as neural interfaces in bioelectronics medicine - Th
 omas Stieglitz\, Professor for Biomedical Microtechnology
DTSTART:20210311T160000Z
DTEND:20210311T170000Z
UID:TALK157624@talks.cam.ac.uk
CONTACT:Kirsty Shepherd
DESCRIPTION:Neural interfaces cover the wet interface between electronic a
 nd biological circuits and systems. They need to establish stable and reli
 able functional interfaces to the target structure in chronic application 
 in neuroscientific experiments but especially in clinical applications in 
 humans. Proper selection of substrate\, insulation and electrode materials
  is of utmost importance to bring the interface in close contact with the 
 neural target structures\, minimize foreign body reaction after implantati
 on and maintain functionality over the complete implantation period. Our w
 ork has focused on polymer substrates with integrated thin-film metallizat
 ion as core of our flexible neural interfaces approach and silicone rubber
  with metal sheets. Micromachining and laser structuring are the main tech
 nologies for electrode array manufacturing. Different design and developme
 nt aspects from the first idea to first-in-human studies are presented and
  discussed. Reliability data from long-term ageing studies and chronic exp
 eriments show the applicability of thin-film implants for stimulation and 
 recording and ceramic packages for electronics protection. Examples of sen
 sory feedback after amputation trauma\, vagal nerve stimulation to treat h
 ypertension and chronic recordings from the brain surface display opportun
 ities and challenges of these miniaturized implants. System assembly and i
 nterfacing microsystems to robust cables and connectors still is a major c
 hallenge in translational research and transition of research results into
  medical products.
LOCATION:Meeting ID: 837 8058 8985 Passcode: 428653
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