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SUMMARY:We were unable to deliver your parcel:  Tumour biophysics and drug
  delivery - Sally Peyman\, University of Leeds
DTSTART:20210303T103000Z
DTEND:20210303T113000Z
UID:TALK157738@talks.cam.ac.uk
CONTACT:Anne Jacobs
DESCRIPTION:There are many promising new drugs and delivery routes in deve
 lopment in the fight against cancer but there remains a fundamental knowle
 dge gap in the translation of discovery science to the clinic: the tumour 
 biophysical microenvironment. \nAggressive tumours are hallmarked by a den
 se\, hypoxic\, mechanically stiff stroma that not only accelerates disease
  progression\, but provides a physical barrier to drug delivery. High dens
 ities of cells and extracellular matrix (ECM) proteins and high interstiti
 al pressures block the penetration of drugs into the tumour mass\, leading
  to long term treatment failure. Yet despite this\, most pre-clinical test
 ing is performed on models that neglect to incorporate critical biophysica
 l features of the tumour microenvironment\, including hydraulic and mechan
 ical accuracy.\nOrgan-on-chip is a branch of microfluidics that allows the
  culture of cells in devices that provides a means to mimic some of the bi
 ophysical features present in tumours in the body. This allows for a more 
 accurate test bed for assessing new drugs. In addition\, these devices pro
 vide models for investigative research into the mechanism of new delivery 
 approaches\, which is not easily achievable in vivo.\nI will present recen
 t work from my group on understanding the biophysical properties of tumour
 s using rheology and AFM in order to develop more accurate pre-clinical te
 st beds and how we use organ-on-chip devices to assess new methods for del
 ivering treatments\, including microbubble enhanced drug delivery.\n
LOCATION:https://zoom.us/j/94270162364?pwd=VTBVMGhUTEttNHlkaGRtcFF2TzdUUT0
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