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SUMMARY:The anterior insular cortex in the rat exerts an inhibitory influe
 nce over the loss of control of heroin intake and subsequent propensity to
  relapse - Dhaval Joshi\, Department of Psychology\, University of Cambrid
 ge
DTSTART:20210303T160000Z
DTEND:20210303T170000Z
UID:TALK157819@talks.cam.ac.uk
CONTACT:Katharina Zuhlsdorff
DESCRIPTION:The anterior insular cortex (AIC) has been implicated in addic
 tive behaviour\, including the loss of control over drug intake\, craving 
 and the propensity to relapse. Evidence suggests that the influence of the
  AIC on drug-related behaviours is complex as in rats exposed to extended 
 access to cocaine self-administration\, the AIC was shown to exert a state
 -dependent\, bidirectional influence on the development and expression of 
 loss of control over drug intake\, facilitating the latter but impairing t
 he former. However\, it is unclear whether this influence of the AIC is co
 nfined to stimulant drugs that have marked peripheral sympathomimetic and 
 anxiogenic effects or whether it extends to other addictive drugs\, such a
 s opiates\, that lack overt acute aversive peripheral effects. We investig
 ated in outbred rats the effects of bilateral excitotoxic lesions of AIC i
 nduced both prior to or after long-term exposure to extended access heroin
  self-administration\, on the development and maintenance of escalated her
 oin intake and the subsequent vulnerability to relapse following abstinenc
 e. Compared to sham surgeries\, pre-exposure AIC lesions had no effect on 
 the development of loss of control over heroin intake\, but lesions made a
 fter a history of escalated heroin intake potentiated escalation and also 
 enhanced responding at relapse. These data show that the AIC inhibits or l
 imits the loss of control over heroin intake and propensity to relapse\, i
 n marked contrast to its influence on the loss of control over cocaine int
 ake.
LOCATION:Zoom
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