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SUMMARY:Structure-function coupling in brain networks - Dr Bratislav Misic
 \, McGill University
DTSTART:20210311T150000Z
DTEND:20210311T160000Z
UID:TALK157831@talks.cam.ac.uk
CONTACT:Sarah Morgan
DESCRIPTION:Structure-function relationships are a fundamental principle o
 f many naturally occurring systems\, including brain networks.  Collective
  communication among connected neuronal populations is thought to support 
 patterned neural activity\, as well as flexible cognitive operations and c
 omplex behavior. Cognitive dysfunction\, due to aging or disease\, may ari
 se from perturbations in structure-function coupling.  Traditional account
 s assume uniform structure-function coupling throughout the brain\, and of
 ten leave out important biological detail. Here I will focus on three new 
 directions to study structure-function coupling: (1) multiplexed models th
 at allow regionally heterogeneous structure-function relationships\, (2) b
 rain networks annotated with micro-architectural features\, and (3) redefi
 ning function as a computational property. Altogether\, I hope to show tha
 t structural network reconstructions enriched with local molecular and cel
 lular metadata\, in concert with more nuanced representations of functions
  and properties\, hold great potential for a truly multiscale understandin
 g of the structure–function relationship. 
LOCATION:Online
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