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SUMMARY:Stabilization of Protein-Protein Interactions\; from biophysical c
 oncept to medicinal chemistry application - Prof. Luc Brunsveld\, Eindhove
 n University of Technology 
DTSTART:20210324T103000Z
DTEND:20210324T113000Z
UID:TALK158032@talks.cam.ac.uk
CONTACT:Anne Jacobs
DESCRIPTION:Our group combines organic synthesis\, protein chemistry\, str
 uctural biology\, and supramolecular chemistry to perform chemical biology
  studies on protein-protein interactions (PPIs) with the aim to enable inn
 ovative medicinal chemistry for ‘molecular glues’ for PPIs. In this pr
 esentation I aim to show that a “supramolecular” point of view to prot
 ein-protein interactions (PPIs) helps to unravel the underlying\, more com
 plex\, interaction mechanisms. This conceptual approach to PPIs allows to 
 recognize and apply concepts such as multivalency and cooperativity within
  the context of drug discovery. Using nuclear receptors and 14-3-3 protein
 s as examples this presentation aims to provide insights into questions su
 ch as\n1)	How can chemical biology studies steer medicinal chemistry for P
 PIs?\n2)	What are the key biophysical characteristics of molecules that st
 abilize PPIs?\n3)	How can we find chemical starting point for PPI stabiliz
 ation?\n
LOCATION:https://zoom.us/j/97842548910
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