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SUMMARY:Not just corpse removal: How microglial phagocytosis maintains tis
 sue homeostasis - Amanda Sierra\, Basque Center for Neuroscience\, Spain
DTSTART:20210412T150000Z
DTEND:20210412T160000Z
UID:TALK158227@talks.cam.ac.uk
CONTACT:47293
DESCRIPTION:Microglia are the brain professional macrophages and they effi
 ciently remove dead cells and other forms of cell debris\, both during dev
 elopment and in pathological conditions. But what happens to microglia aft
 er engulfing and degrading apoptotic cells? In this talk\, I will argue th
 at phagocytosis is not a dead-end process but rather the begging of a new 
 life for microglia. I will discuss that the events triggered in microglia 
 by phagocytosis have an impact on the surrounding tissue\, using as a mode
 l the adult neurogenic cascade\, where microglia engulfs the excess of new
 born cells. We are currently learning how phagocytosis affects microglial 
 metabolism\, transcription\, and cell function\, with the goal of developi
 ng pharmacological approaches to harness microglial phagocytosis in the di
 seased brain.
LOCATION:https://zoom.us/j/92158313741?pwd=YTRkUGJQcklWSnJrcGhmQTdiSkZPQT0
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