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SUMMARY:Early constipation predicts faster dementia onset in Parkinson’s
  disease - Marta Camacho\, Department of Clinical Neurosciences
DTSTART:20210317T160000Z
DTEND:20210317T170000Z
UID:TALK158239@talks.cam.ac.uk
CONTACT:Katharina Zuhlsdorff
DESCRIPTION:Constipation is a common but not a universal feature in early 
 PD\, suggesting that gut involvement is heterogeneous and may be part of a
  distinct PD subtype with prognostic implications. We analysed data from t
 he Parkinson’s Incidence Cohorts Collaboration\, composed of incident co
 mmunity-based cohorts of PD patients assessed longitudinally over 8 years.
  Constipation was assessed with the MDS-UPDRS constipation item or a compa
 rable categorical scale. Primary PD outcomes of interest were dementia\, p
 ostural instability and death. PD patients were stratified according to co
 nstipation severity at diagnosis: none (n=313\, 67.3%)\, minor (n=97\, 20.
 9%) and major (n=55\, 11.8%). Clinical progression to all 3 outcomes was m
 ore rapid in those with more severe constipation at baseline (Kaplan Meier
  survival analysis). Cox regression analysis\, adjusting for relevant conf
 ounders\, confirmed a significant relationship between constipation severi
 ty and progression to dementia\, but not postural instability or death. Ea
 rly constipation may predict an accelerated progression of neurodegenerati
 ve pathology.
LOCATION:Zoom
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