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SUMMARY:Cortical and subcortical grey matter micro-structure is associated
  with polygenic risk for schizophrenia - Eva-Maria Stauffer\, Department o
 f Psychiatry
DTSTART:20210324T160000Z
DTEND:20210324T170000Z
UID:TALK158467@talks.cam.ac.uk
CONTACT:Katharina Zuhlsdorff
DESCRIPTION:Background: Recent discovery of hundreds of common gene varian
 ts associated with schizophrenia has enabled polygenic risk scores (PRS) t
 o be measured in the population. It is hypothesized that normal variation 
 in genetic risk of schizophrenia should be associated with MRI changes in 
 brain morphometry and tissue composition. Methods: We used the largest ext
 ant genome-wide association dataset (N = 69\,369 cases and N = 236\,642 he
 althy controls) to measure PRS for schizophrenia in a large sample of adul
 ts from the UK Biobank (Nmax = 29\,878) who had multiple micro- and macro-
 structural MRI metrics measured at each of 180 cortical areas and seven su
 bcortical structures. Linear mixed effect models were used to investigate 
 associations between schizophrenia PRS and brain structure at global and r
 egional scales\, controlled for multiple comparisons. Results: Micro-struc
 tural phenotypes were more robustly associated with schizophrenia PRS than
  macro-structural phenotypes. Polygenic risk was significantly associated 
 with reduced neurite density index (NDI) at global brain scale\, at 149 co
 rtical regions\, and five subcortical structures. Other micro-structural p
 arameters\, e.g.\, fractional anisotropy\, that were correlated with NDI w
 ere also significantly associated with schizophrenia PRS. Genetic effects 
 on multiple MRI phenotypes were co-located in temporal\, cingulate and pre
 frontal cortical areas\, insula\, and hippocampus. (Preprint: https://www.
 medrxiv.org/content/10.1101/2021.02.06.21251073v1)
LOCATION:Zoom
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