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SUMMARY:Non-canonical ventral pallidal circuits and their relevance for tr
 eating addiction - Dr Meaghan Creed\, Washington University School of Medi
 cine in St. Louis
DTSTART:20211014T113000Z
DTEND:20211014T123000Z
UID:TALK158470@talks.cam.ac.uk
CONTACT:Dr Valerie Voon
DESCRIPTION:*Abstract*\nThe ventral pallidum is a brain area which is crit
 ically important for assessing hedonic value of reward and encoding motiva
 tional drive. Classically\, the VP is considered an inhibitory ‘relay’
  between the nucleus accumbens and midbrain structures. Our recent work ch
 allenges this model of information flow in the basal ganglia. We character
 ize two non-canonical populations of ventral pallidal neurons: 1) ventral 
 pallidal glutamatergic neurons which follow canonical output pathways\, bu
 t exert opposing excitatory drive on downstream structures\, and 2) arkypa
 llidal neurons\, which robustly innervate and inhibit the nucleus accumben
 s in a value-dependent manner. We show that these populations are critical
  for constraining reward seeking in the face of aversive consequences\, an
 d encoding reward palatability to promote consumption\, respectively. We d
 iscuss how adaptations in these pathways undergo adaptations that contribu
 te to symptoms of impaired reward processing in the context of substance u
 se disorders\, and how harnessing this cellular heterogeneity may lead to 
 cell-type specific neuromodulation therapies for these disorders.\n\n*Biog
 raphy*\nDr Meaghan Creed obtained her HBSc and PhD in Pharmacology at the 
 University of Toronto in Canada\, then moved to Geneva Switzerland for pos
 t-doctoral training. Throughout her career\, she has focused on understand
 ing and optimizing deep brain stimulation (DBS) applied to the basal gangl
 ia for neurological and psychiatric disorders. Now an assistant professor 
 at the WashU Pain center\, she and her team are working to develop new neu
 romodulation therapies to treat symptoms at the interface of chronic pain\
 , addiction and mood disorders. For detailed biography of Dr Creed\, pleas
 e visit: https://www.creedlab.org/meaghan-creed.html
LOCATION: Webinar  (via Zoom online)
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