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SUMMARY:Mechanics of embryonic self-organization - Dr. Jérôme Gros (Inst
 itut Pasteur\, Paris) &amp\; Dr. Francis Corson (Ecole Normale Supérieure
 \, Paris)
DTSTART:20210331T160000Z
DTEND:20210331T170000Z
UID:TALK158698@talks.cam.ac.uk
CONTACT:Dr. Adrien Hallou
DESCRIPTION:Mechanical forces play an essential role in development\, most
  evidently as the drivers of morphogenesis\, but also potentially as long-
 range signals contributing to embryonic self-organization. Regulative deve
 lopment is particularly evident in experiments in which the avian embryoni
 c disk is bisected: each half can give rise to a fully-formed embryo\, imp
 lying a dramatic redirection of force generation and gene expression. Havi
 ng identified a contractile ring\, at the boundary between the embryonic a
 nd extra-embryonic territories\, as the engine of early avian morphogenesi
 s\, we wondered whether tension along the embryo margin might underlie emb
 ryonic regulation. Indeed\, a mechanical analog of a Turing model\, in whi
 ch contractility plays the role of activator\, and tension the role of inh
 ibitor\, recapitulates the steady pattern of tissue motion in intact embry
 os and its redirection upon bisection. We further show that mechanical fee
 dback also impinges on gene expression\, driving the emergence of ectopic 
 embryos and the accompanying rescaling of embryonic territories. Our findi
 ngs demonstrate a central role for mechanical forces in embryonic self-org
 anization and cell fate allocation.
LOCATION:Webinar
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