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SUMMARY:Distribution and regulation of ion channels in neurons:  Quantitat
 ive studies of global protein transport and homeostatic synaptic scaling -
  Adriano Bellotti\, University of Cambridge
DTSTART:20210408T130000Z
DTEND:20210408T140000Z
UID:TALK158743@talks.cam.ac.uk
CONTACT:Thiago Burghi
DESCRIPTION:A healthy neuron must continually produce millions of proteins
  and distribute them to function-specific regions of the cell.  Among thes
 e proteins are ion channels that modulate neuronal excitability\, allowing
  neurons to fulfill their primary role of information transfer.  Neurons a
 re unique among cells in their morphology\, with projections that extend h
 undreds to thousands of microns.  Neuron size and asymmetry pose a challen
 ge for autoregulation of properties that require cargo transport across th
 e cell.  Homeostasis of ion channel localization has strong implications f
 or neural excitability.  This thesis concerns the intracellular distributi
 on of ion channels in the context of longitudinal transport and global neu
 ron regulation.  \n\nThe principal contributions are experimental measurem
 ents\, data analysis\, and modeling in the study of longitudinal neurite t
 ransport.  Empirical investigations focus on the distribution and traffick
 ing kinetics of ion channel Kv4.2\, including quantitative measurements of
  both passive diffusion and active microtubule-based transport in both axo
 ns and dendrites.  Mass action models reveal that measured transport profi
 les corroborate discrepancies in Kv4.2 localization both between neurite t
 ypes and along the somatodendritic axis.  Further\, theoretical study surv
 eys global regulation of ion channels\, specifically for synaptic scaling\
 , which requires cell-wide modulation of AMPA receptors for normalization 
 of neural excitability.  A unified model of synaptic potentiation\, transp
 ort\, and feedback reveals limitations imposed on synaptic scaling by neur
 on morphology.  A neuron balances the stability\, accuracy\, and efficienc
 y of synaptic scaling.\n\nZoom meeting link: https://zoom.us/j/99231423419
   
LOCATION:Online (Zoom)
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