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SUMMARY:The switch from choice to commitment: an example from HIV  - Dr. M
 aike Hansen\, Radboud University Nijmegen
DTSTART:20210428T093000Z
DTEND:20210428T103000Z
UID:TALK158779@talks.cam.ac.uk
CONTACT:Anne Jacobs
DESCRIPTION:Gene expression is an example of a complex multistep cellular 
 reaction\, where variability in reaction outcome can convey distinct pheno
 typic properties.  Results show that about 85% of genes across diverse pro
 moters\, genomic loci\, and cell types (human and mouse) exhibit a high de
 gree of rate-driven noise amplification.  An additional cytoplasmic noise-
 amplification step leads to large variability in protein levels.  This rai
 ses the important question of how efficient noise attenuation can be achie
 ved\, for example during human immunodeficiency virus (HIV) fate-commitmen
 t.  Our data reveals that after a noise-driven event\, HIV implements an e
 fficient post-transcriptional negative-feedback which minimizes gene expre
 ssion variability and stabilizes viral fate.\n\n
LOCATION:https://zoom.us/j/92521025039
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