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SUMMARY:Adaptation of Mycobacterium tuberculosis to growth as a biofilm - 
 Professor Caitlin Pepperell\, School of Medicine and Public Health\, Unive
 rsity of Wisconsin Madison
DTSTART:20210519T150000Z
DTEND:20210519T160000Z
UID:TALK158929@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Tuberculosis (TB)\, caused by Mycobacterium tuberculosis (M. t
 b)\, is a leading cause of death due to infectious disease. TB is not trad
 itionally associated with biofilms\, but M. tb biofilms are linked with dr
 ug and immune tolerance and there is increasing recognition of their poten
 tial role in the recalcitrance of TB infections. Here we used M. tb experi
 mental evolution to investigate this complex phenotype and identify candid
 ate loci controlling biofilm formation. We identified novel candidate loci
 \, adding to our understanding of the genetic architecture underlying M. t
 b biofilm development. Under selective pressure to grow as a biofilm\, reg
 ulatory mutations rapidly swept to fixation and were associated with chang
 es in multiple traits including extracellular matrix production\, cell siz
 e\, and growth rate. Genetic and phenotypic paths to enhanced biofilm grow
 th varied according to the genetic background of the parent strain\, sugge
 sting that epistatic interactions are important in M. tb adaptation to cha
 nging environments.\n\n\n\nChaired by Dr Lucy Weinert
LOCATION:Zoom: https://zoom.us/j/834693107?pwd=SzhzMXdPbmJJOHJubEFpZm8rVnR
 kZz09  Meeting ID: 834 693 107 - Passcode: 533456
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