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SUMMARY:‘Fine-tuning cell mechanics at the onset of collective cell moti
 on’ - Elias H Barriga\, Group Leader at Mechanisms of Morphogenesis Lab\
 , Instituto Gulbenkian de Ciência (IGC)\, Oeiras\, Portugal
DTSTART:20210426T133000Z
DTEND:20210426T143000Z
UID:TALK159091@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:The synchronisation of major morphogenetic events such as coll
 ective cell migration (CCM) has been recently shown to emerge from the mec
 hanical interaction between tissues. Yet\, whether interacting tissues bal
 ance their elastic properties and the molecular mechanism that mediates th
 is process remains unclear. To address this\, we explored the recently est
 ablished mechanical interplay between neural crest (NCs)\, a mechanosensit
 ive cell population and its migratory substrate\, the mesoderm. Combining 
 in vivo experiments with biophysical and theoretical approaches we reveale
 d that NC and mesoderm tend to match their elastic properties over time le
 ading to NCs fluidisation and CCM. Strikingly\, NCs fluidisation is fine-t
 uned by microtubule acetylation via a novel mechanosensitive pathway invol
 ving Piezo1 regulation of the de-acetylase Hdac6. Overall\, our data posit
 ions microtubule de-acetylation as a key mediator of the mechanomolecular 
 feedback-loops that synchronise morphogenetic events.\n 
LOCATION:Online
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