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SUMMARY:Wisdom of the crowd – Mechanisms that coordinate individual cell
  movements for epithelial migration  - Sally Horne-Badovinac\, University 
 of Chicago
DTSTART:20210510T133000Z
DTEND:20210510T143000Z
UID:TALK159103@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:The collective migration of epithelial cells underlies tissue 
 remodeling events associated with morphogenesis\, intestinal turnover\, wo
 und repair\, and cancer. For an epithelium to migrate in a directed way\, 
 the cytoskeletal machinery that powers each cell’s motility must become 
 aligned in the direction of tissue movement. Using the follicular epitheli
 um of Drosophila\, my lab studies how this tissue-level alignment is achie
 ved. In the first part of the talk\, I will discuss our work on a planar s
 ignaling system that determines where leading-edge protrusions form in eac
 h cell\, as well as our efforts to understand how these initially local si
 gnals are propagated to polarize the epithelium for directed migration. In
  the second part of the talk\, I will discuss how a parallel array of stre
 ss fibers at each cell’s basal surface may reinforce collective migratio
 n by ensuring that all of the cells in the tissue maintain a linear trajec
 tory. \n\n 
LOCATION:Online
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