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SUMMARY:Brief Sensory Deprivation Triggers Cell Type-Specific Structural a
 nd Functional Plasticity in Olfactory Bulb Neurons - Li Huang\, Joseph Inn
 es\, Emily Winson-Bushby\, University of Cambridge
DTSTART:20210428T150000Z
DTEND:20210428T160000Z
UID:TALK159700@talks.cam.ac.uk
CONTACT:Katharina Zuhlsdorff
DESCRIPTION:Can alterations in experience trigger different plastic modifi
 cations in neuronal structure and function\, and if so\, how do they integ
 rate at the cellular level? To address this question\, we interrogated cir
 cuitry in the mouse olfactory bulb responsible for the earliest steps in o
 dor processing. We induced experience-dependent plasticity in mice of eith
 er sex by blocking one nostril for one day\, a minimally invasive manipula
 tion that leaves the sensory organ undamaged and is akin to the natural tr
 ansient blockage suffered during common mild rhinal infections. We found t
 hat such brief sensory deprivation produced structural and functional plas
 ticity in one highly specialized bulbar cell type: axon-bearing dopaminerg
 ic neurons in the glomerular layer. After 24 h naris occlusion\, the axon 
 initial segment (AIS) in bulbar dopaminergic neurons became significantly 
 shorter\, a structural modification that was also associated with a decrea
 se in intrinsic excitability. These effects were specific to the AIS-posit
 ive dopaminergic subpopulation because no experience-dependent alterations
  in intrinsic excitability were observed in AIS-negative dopaminergic cell
 s. Moreover\, 24 h naris occlusion produced no structural changes at the A
 IS of bulbar excitatory neurons\, mitral/tufted and external tufted cells\
 , nor did it alter their intrinsic excitability. By targeting excitability
  in one specialized dopaminergic subpopulation\, experience-dependent plas
 ticity in early olfactory networks might act to fine-tune sensory processi
 ng in the face of continually fluctuating inputs.
LOCATION:Zoom
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