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SUMMARY:Membrane-associated charge and the cardiac electrical field - Andr
 ew Grace\, Honorary Professor of Experimental Cardiology\, Department of B
 iochemistry\; Consultant Cardiologist\, Royal Papworth Hospital
DTSTART:20210520T150000Z
DTEND:20210520T160000Z
UID:TALK159910@talks.cam.ac.uk
CONTACT:Kirsty Shepherd
DESCRIPTION:Macroscopic recordings of the cardiac electrical field were fi
 rst obtained empirically in the late 19th century and through the electroc
 ardiogram provided platform technologies allowing clinical cardiology to f
 lourish. Physical first principles dictate that these fields must originat
 e from charge movements across cardiac cell membranes and we now show clin
 ically that charge density calculations precisely locate the sources of th
 e field. Such localization has significantly enhanced treatment efficacy. 
 Furthermore\, the charge-based model allows a direct route to integration 
 starting from charge movements in structurally resolved intramembrane chan
 nels through Hodgkin-Huxley formalism to body surface recordings. These co
 nstructs provide a means to resolve the biology underlying the generation 
 of the cardiac rhythm and design targeted therapeutics. 
LOCATION:Meeting ID: 837 8058 8985 Passcode: 428653
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