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SUMMARY:Cellular Organization Through Liquid-Liquid Phase Separation - Pro
 f. Michael Rosen\, Department of Biophysics\, University of Texas 
DTSTART:20210512T150000Z
DTEND:20210512T160000Z
UID:TALK160264@talks.cam.ac.uk
CONTACT:Akhila Kadgathur Jayaram
DESCRIPTION:Biomolecular condensates are two- and three-dimensional compar
 tments in eukaryotic cells that concentrate specific collections of protei
 ns and nucleic acids without an encapsulating membrane. Many condensates b
 ehave as dynamic liquids\, and are believed to form through liquid-liquid 
 phase separation (LLPS) driven by interactions between multivalent constit
 uents. While we understand much about the physical mechanisms that promote
  and regulate LLPS\, we know less about the biochemical functions that ari
 se from this process\, and many roles of LLPS in biology remain to be disc
 overed. In my talk I will explain how my lab began our work on biological 
 LLPS\, and then discuss how assembly of two distinct signaling cascades in
 to condensates causes modulation of their biochemical activities. Finally\
 , I will discuss a new direction in the lab focused on understanding how c
 hromatin may be organized by LLPS\, and dynamically regulated by various r
 emodeling machineries. These behaviors may contribute to formation of func
 tionally distinct compartments in the eukaryotic nucleus\, which are impor
 tant to processes including gene regulation and DNA repair.
LOCATION:https://zoom.us/j/97334125524
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