BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Talks.cam//talks.cam.ac.uk// X-WR-CALNAME:Talks.cam BEGIN:VEVENT SUMMARY:Single molecule electrometry: "\;far-field"\; electrostati c fingerprints of molecular 3D conformation and shape - Professor Madhavi Krishnan ( University of Oxford) DTSTART:20210521T093000Z DTEND:20210521T103000Z UID:TALK160267@talks.cam.ac.uk CONTACT:Akhila Kadgathur Jayaram DESCRIPTION:We recently developed a field free technique to trap and measu re the electrical charge of single molecules in solution with sub-elementa ry charge precision. Such measurements open doors to a host of high precis ion measurement and detection problems in biophysics and soft matter. One problem that we have been interested in from the start concerns the relati onship between the 3D structure of a charged molecule and its "electrostat ic fingerprint" in the far field. Here I will talk about how high precisio n measurements of molecular effective charge in solution enable us to glea n information on molecular 3D structure and conformation in solution. Usin g DNA origami we are able to measure differences in molecular topology rap idly and with high precision\, and to readily distinguish molecular isofor ms that carry identical amounts of structural charge. Taking the measureme nt further\, we have demonstrated the ability to measure the rise per base pair and radius of different forms of the double helix with up to sub-Angs trom precision\, traditionally attained using techniques such as x-ray cry stallography\, and NMR in the solution phase. LOCATION: https://zoom.us/j/95836951805 END:VEVENT END:VCALENDAR